Jian Yang

About

Looking up, I observe the immensity of the cosmos; bowing my head, I examine the multitude of the world. Thus, I let my eyes wander and my mind roam freely, fully enjoying the pleasures of sight and sound—what a true delight it is! 仰观宇宙之大,俯察品类之盛,所以游目骋怀,足以极视听之娱,信可乐也。 Academic Profile Medical Doctor (M.D.), specializing in: Evolutionary genomics and comparative genomics to analyze adaptive evolution and neural regenerative capacity; Bioinformatics and patch-clamp neuroelectrophysiology to investigate spinal cord development patterns, molecular mechanisms, intrinsic regenerative pathways, and microenvironment reconstruction for spinal repair and functional recovery; Molecular mechanisms and therapeutic agents for neurodegenerative diseases in Parkinson’s models. Professional Experience Former Roles: First Research Assistant to Academician, Key Laboratory of Neuroregeneration, Ministry of Education, Jiangsu Province; Director of Bioinformatics and Patch-Clamp Electrophysiology Platform, Key Laboratory of Neuroregeneration (MOE); Experimentalist, NMPA Key Laboratory for Tissue Engineering Technology Products Research and Evaluation. Current: Neurologist, Neurological Disease Center, Deyang People’s Hospital Affiliated to Chengdu University of Traditional Chinese Medicine. Research Focus Long-term dedication to multi-omics integration (genomics, transcriptomics) combined with experimental validation to study: Neurodegenerative diseases (e.g., Parkinson’s pathology); Neural development and regenerative repair mechanisms; Spinal cord regeneration microenvironment reconstruction via bioinformatics and patch-clamp electrophysiology. Key Achievements Publications: 23 SCI-indexed papers with cumulative Impact Factor: 174.2 5 papers with IF > 10 (5-year impact factor); 6 CAS Zone 1 papers (5 TOP journals); 10 CAS Zone 2 papers (4 TOP journals); 19 JCR Q1 papers, 3 JCR Q2 papers. Research cited by Nature, Reuters, and Science and Technology Daily; Oxford University Press "Top 10% Read" award. Mentorship: Supervised 3 Ph.D. candidates (Nanjing University of Chinese Medicine & Jiangsu Provincial Hospital of Traditional Chinese Medicine); Guided 2 M.S. students (Neurobiology, Nantong University). Projects & Grants: Co-investigator: 3 NSFC General Projects; 1 NSFC Key Project (led by Academician); 1 Jiangsu Provincial Priority Academic Program; 1 Sichuan Provincial Key R&D Project. Principal Investigator: 1 Talent Project (Nantong University); 1 MOE Key Laboratory Project (Tongji University). Awards: First Prize, Huaxia Medical Science and Technology Award; Second Prize, Natural Science Award of MOE Higher Education Outstanding Research. Leadership & Service Director, Bioinformatics and Patch-Clamp Electrophysiology Platform, MOE Key Laboratory of Neuroregeneration; Experimentalist, NMPA Key Laboratory for Tissue Engineering; Founding Member: China Spinal Cord Injury Repair and Functional Reconstruction Alliance; CPAM Smart Healthcare and Intelligent Medicine Branch; Senior Member, Jiangsu Association for Science and Technology; Member, China Computer Federation (CCF); Mentor for Ph.D./M.S. candidates (NJUCM & Jiangsu Provincial Hospital); Lecturer, Bioinformatics Graduate Course, MOE Key Laboratory of Neuroregeneration (Nantong University); Review Expert: Research Equipment Bidding (Nantong University); Entrance Exam Designer for Tertiary Hospitals; First Research Assistant to Chinese Academy of Engineering Academician; Peer Reviewer for multiple SCI journals (awarded "Outstanding Reviewer").

Work

People's Hospital of Deyang City
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M.D.

China

Key Laboratory of Neuroregeneration of Jiangsu and the Ministry of Education

China

Education

Soochow University
China

Doctor of Medicine(M.D.)

Nantong University
China

Master's degree

Publications

Convergent and divergent transcriptional reprogramming of motor and sensory neurons underlying response to peripheral nerve injury

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Journal of Advanced Research

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Genome-wide profiling and functional characterization of circular RNAs in neural development and injury: insights from a rat model research

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Cellular and Molecular Life Sciences

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VCF2Dis: an ultra-fast and efficient tool to calculate pairwise genetic distance and construct population phylogeny from VCF files

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GigaScience

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Bilateral Thalamic Edema Caused by Tentorial Galenic Dural Arteriovenous Fistula and Sinus Thrombosis: Successful Endovascular Therapy

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Turkish Neurosurgery

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Biomimetic-inspired piezoelectric ovalbumin/BaTiO3 scaffolds synergizing with anisotropic topology for modulating Schwann cell and DRG behavior

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International Journal of Biological Macromolecules

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VCF2PCACluster: a simple, fast and memory-efficient tool for principal component analysis of tens of millions of SNPs

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BMC Bioinformatics

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Cartilage stem/progenitor cells‐derived exosomes facilitate knee cartilage repair in a subacute osteoarthritis rat model

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Journal of Cellular and Molecular Medicine

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Skin derived precursors induced Schwann cells mediated tissue engineering-aided neuroregeneration across sciatic nerve defect

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Bioactive Materials

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Exosomes derived from primary cartilage stem/progenitor cells promote the repair of osteoarthritic chondrocytes by modulating immune responses

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International Immunopharmacology

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Integrative mRNA and miRNA Expression Profiles from Developing Zebrafish Head Highlight Brain-Preference Genes and Regulatory Networks

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Molecular Neurobiology

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NGenomeSyn: an easy-to-use and flexible tool for publication-ready visualization of syntenic relationships across multiple genomes

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Bioinformatics

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Integrated analyses reveal evolutionarily conserved and specific injury response genes in dorsal root ganglion ( Article Type: Analysis)

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Scientific Data

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Deciphering the dynamic niches and regeneration-associated transcriptional program of motoneurons following peripheral nerve injury

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iScience

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Deciphering the dynamic niches and regeneration-associated transcriptional program of motoneurons following peripheral nerve injury

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iScience

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Evolution of the ErbB gene family and analysis of regulators of Egfr expression during development of the rat spinal cord

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Neural Regeneration Research

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Developmental Temporal Patterns and Molecular Network Features in the Transcriptome of Rat Spinal Cord (Section: Tissue engineering)

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Engineering

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Klf2-Vav1-Rac1 axis promotes axon regeneration after peripheral nerve injury.

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Experimental neurology

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Molecular Regulatory Mechanism and Toxicology of Neurodegenerative Processes in MPTP/Probenecid-Induced Progressive Parkinson’s Disease Mice Model Revealed by Transcriptome

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Molecular Neurobiology

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Speciation and adaptive evolution reshape antioxidant enzymatic system diversity across the phylum Nematoda

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BMC Biology

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Anisotropic ridge/groove microstructure for regulating morphology and biological function of Schwann cells

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Applied Materials Today

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Comparison of neural stem/progenitor cells from adult Gecko japonicus and mouse spinal cords

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Experimental Cell Research

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The Landscape of Gene Expression and Molecular Regulation Following Spinal Cord Hemisection in Rats

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Frontiers in Molecular Neuroscience

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Gekko japonicus genome reveals evolution of adhesive toe pads and tail regeneration.

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Nature communications

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Different Astrocytic Activation between Adult Gekko japonicus and Rats during Wound Healing In Vitro.

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PloS one

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